Tubbler labs11/19/2022 ![]() Antibody Liability RemovalĮnsuring your candidate is ready for the clinic is one of the most challenging steps in antibody discovery. Tumbler - Rapid Optimizationįigure 2: Kinetics graph demonstrating the rapid optimization in antibody affinity Tumbler provides, over 10x greater binding activity in both cyno and human targets. Not only does Tumbler provide a single affinity-improved version, you will also receive an entire panel of antibodies with varying paratopes for you to analyze and select the best version. Tumbler provides an optimal affinity maturation tool that can increasing your antibody candidate’s binding as much as two log KD, or 130x improved. Antibody humanization with Tumbler far exceeds chimeric CDR grafting.įigure 1: Antibody lead candidate results from Tumbler that show the candidate is demonstrating greater than 90% human structural characteristics while retaining or improving antibody affinity. Your antibody is ‘tumbled’ through our proprietary technology, producing an antibody candidate that is identical to human antibody structure and behavior. What can Antibody Optimization do for Your Antibodies? 1. Tumbler can also be used to retrofit antibodies to cross to a new version of the original target providing an avenue to repurpose drug and lead candidates, creating a cost-effective route of drug discovery. Delivering fully-human therapeutic-ready antibodies improved for affinity, potency, cross-reactivity, specificity, and biophysical attributes. Tumbler is designed to enhance the therapeutic or diagnostic performance of any antibody candidate, regardless of format. Tumbler provides simultaneous, multi-factor antibody engineering and optimization for antibody candidates discovered from our antibody libraries, or from your own development. Our Commitment to Diversity, Equity & Inclusionįast, Robust Antibody Optimization With Tumbler.Agrochemical Testing Services for Approvals.Scientific Staffing, Training, & Operations Support.Scientific & Regulatory Advisory Services.Tungsten VHH Library for Nanobody Discovery.SuperHuman Antibody Library for Antibody Discovery.Cosmic Antibody Library for Antibody Discovery.Phage Antibody Discovery and Antibody Engineering Toggle menu. ![]() Biologics Discovery and Protein Engineering Toggle menu.Physical Characterization & Pharmaceutical Sciences.Can also take a while to empty the res after harvest. It's between grows that the problems lie. No need to change the res during the grow.Įasy as during the grow. #Tubbler labs fullOnce a week, measure ec and use a cheat sheet to addback enough (GH) Micro and Bloom to bring the ec back to full strength. Very large res of RO water with auto top up. If you want easy peasy dwc, I've done this and it works: How close to the sun can Icarus fly before it's bad news? How safe do you want to play it? Warmer = faster growth with the risk of root rot. No way can an rwdc beat that although it might get fairly close to equal. Have a res that is almost the same size as your grow area. Easier and better than rwdc is a tubbler. ![]() I'm more worried about water temp and root rot. #Tubbler labs upgradeIf I'm successful I'll upgrade to a decent hlg panel light. Rather have issues with a cheap 1 plant grow than my whole crop. I'm going with a 25ltr bucket I've got lying about (thought it was 20 at first), It will be modified with a sight tube on the side that can be turned and used to drain the bucket and I'll also have a grommet with connector on the top for refilling. When I later used a huge res and a BIG airpump, the yield was plenty good enough. The leaves looked like crap but the yield was just about acceptable. I threw the towel in and stopped adjusting pH between res changes. I had no end of pH problems with 15L reservoirs. ![]() The smaller the dwc res, the quicker the pH goes out. How are you going to change the res? Think that through before starting. With only 5' of height, it's scrog or lst. That's commonly used, a 600w hps covering 4'x4'. You'll be getting 25w psf so equivalent to 37.5w psf of hps. Fwir about led, a decent one is about 50% better than hps. ![]()
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